Article
A novel and efficient murine model of Bietti crystalline dystrophy.
Disease models & mechanisms - 1 Mar 2022
Wang Yafang, Liu Yang, Liu Shu, Li Xiaomeng, Liu Xinxin, Jiao Ming, Yang Yuqin, Luo Xueting, Wang Fenghua, Wan Xiaoling, Sun Xiaodong
Abstract excerpt
Bietti crystalline dystrophy (BCD) is an autosomal recessive inherited retinal disease, resulting in blindness in most patients. The etiology and development mechanism of it remain unclear. Given the defects in previous mouse models of BCD, we generated a new Cyp4v3-/- mouse model, using CRISPR/Cas9 technology, for investigating the pathogenesis of BCD. We estimated the ocular phenotypes by fundus imaging,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.