Article

The coumarin derivative X6632 is a pan-ID protein inhibitor that suppresses tumor growth by targeting cancer cells and the tumor-associated microvasculature

2026-08-05

Abstract excerpt

Inhibitor of DNA binding (ID) proteins are key regulators of tumor cell stemness, therapy resistance and pathological angiogenesis in multiple cancer types and other diseases. Here, we characterize the coumarin-derived compound X6632 as a pan-ID inhibitor with dual activity against tumor cells and the tumor-associated microvasculature in a number of human and murine models. X6632 efficiently suppressed ID protein...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 45101160-fb74-587f-aed7-ac26dfbc63f9
DOI: 10.64898/2026.08.05.742008

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The coumarin derivative X6632 is a pan-ID protein inhibitor that suppresses tumor growth by targeting cancer cells and the tumor-associated microvasculatureDOI 10.64898/2026.08.05.742008Read

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular NeovascularizationSemantic proximity Read

Catestatin suppresses melanoma progression and drug resistance through multitargeted modulation of signaling pathwaysSemantic proximity Read

CDK12 regulates angiogenesis of advanced prostate cancer by IGFBP3Semantic proximity Read

CDC42 Inhibitors Alter Patterns of Vessel Arborization in Skin and Tumors in vivoSemantic proximity Read

The Ashitaba (Angelica keiskei) Chalcones 4-hydroxyderricin and Xanthoangelol Suppress Melanomagenesis By Targeting BRAF and PI3K.Semantic proximity Read

A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylationSemantic proximity Read

MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathwaySemantic proximity Read

Pigment epithelium-derived factor: a multimodal tumor inhibitorSemantic proximity Read

Synchronizing Cancer Research Worldwide, a Way of Overcoming Resistance to Anti-angiogenic DrugsSemantic proximity Read

The Core-Targeted RRM2 Gene of Berberine Hydrochloride Promotes Breast Cancer Cell Migration and Invasion via the Epithelial–Mesenchymal TransitionSemantic proximity Read

Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularitySemantic proximity Read

Superior anti-tumor activity of the MDM2 antagonist idasanutlin and the Bcl-2 inhibitor venetoclax in p53 wild-type acute myeloid leukemia modelsSemantic proximity Read