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Article

Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality.

American journal of respiratory and critical care medicine - 15 Jan 2009

Arcaroli John J, Hokanson John E, Abraham Edward, Geraci Mark, Murphy James R, Bowler Russell P, Dinarello Charles A, Silveira Lori, Sankoff Jeff, Heyland Daren, Wischmeyer Paul, Crapo James D

Abstract excerpt

RATIONALE: Extracellular superoxide dismutase (EC-SOD) is a potent antioxidant that plays an important role in controlling oxidant-mediated stress and inflammation. High levels of EC-SOD are found in the lung. Acute lung injury (ALI) frequently occurs in patients with infection, and levels of EC-SOD have been shown to modulate severity of lung injury in transgenic animal models of endotoxemia-induced ALI. An...

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PMID: 18948423
DOI: 10.1164/rccm.200710-1566OC
PMCID: PMC2633057

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