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Biological Functions of Gasdermins in Cancer: From Molecular Mechanisms to Therapeutic Potential

9 Feb 2021

Abstract excerpt

Pyroptosis is a type of lytic programmed cell death triggered by various inflammasomes that sense danger signals. Pyroptosis has recently attracted great attention owing to its contributory role in cancer. Pyroptosis plays an important role in cancer progression by inducing cancer cell death or eliciting anticancer immunity. The participation of gasdermins (GSDMs) in pyroptosis is a noteworthy recent discovery....

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PMID: 33634141
DOI: 10.3389/fcell.2021.638710

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