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Article

Genome-Scale Characterization of Toxicity-Induced Metabolic Alterations in Primary Hepatocytes

5 Sept 2019

Abstract excerpt

Context-specific GEnome-scale metabolic Network REconstructions (GENREs) provide a means to understand cellular metabolism at a deeper level of physiological detail. Here, we use transcriptomics data from chemically-exposed rat hepatocytes to constrain a GENRE of rat hepatocyte metabolism and predict biomarkers of liver toxicity using the Transcriptionally Inferred Metabolic Biomarker Response algorithm. We...

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PMID: 31501904
DOI: 10.1093/toxsci/kfz197

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