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Article

Knowledge-Driven Approaches to Create the MTox700+ Metabolite Panel for Predicting Toxicity.

Toxicological sciences : an official journal of the Society of Toxicology - 28 Mar 2022

Sostare Elena, Lawson Thomas N, Saunders Lucy R, Colbourne John K, Weber Ralf J M, Sobanski Tomasz, Viant Mark R

Abstract excerpt

Endogenous metabolite levels describe the molecular phenotype that is most downstream from chemical exposure. Consequently, quantitative changes in metabolite levels have the potential to predict mode-of-action and adversity, with regulatory toxicology predicated on the latter. However, toxicity-related metabolic biomarker resources remain highly fragmented and incomplete. Although development of the S1500+ gene...

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PMID: 35094093
DOI: 10.1093/toxsci/kfac007
PMCID: PMC8963288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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