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Article

Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study

22 Apr 2025

Abstract excerpt

Common variants within TMEM106B are associated with risk for frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). The G allele of the top single nucleotide polymorphism, rs1990622, confers protection against FTLD-TDP, including genetic cases due to GRN mutations or C9orf72 hexanucleotide repeat expansions. However, the effects of interaction between TMEM106B-rs1990622 and frontotemporal dementia...

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PMID: 40260680
DOI: 10.1093/brain/awaf019

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