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Article

The mitochondrial genome in human adaptive radiation and disease: on the road to therapeutics and performance enhancement.

Gene - 18 Jul 2005

Wallace Douglas C

Abstract excerpt

The human mitochondrial genome consists of approximately 1500 genes, 37 encoded by the maternally inherited mitochondrial DNA (mtDNA) and the remainder encoded in the nuclear DNA (nDNA). The mtDNA is present in thousands of copies per cell and encodes proteins that are essential components of the mitochondrial energy generation pathway, oxidative phosphorylation (OXPHOS). OXPHOS generates heat to maintain our...

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Identifiers

PMID: 16024186
DOI: 10.1016/j.gene.2005.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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