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Article

Proton therapy re-irradiation outcomes and genomic landscape of patients with recurrent head and neck cancer.

Oral oncology - 1 Jul 2024

Krc Rebecca, Mendes William, Molitoris Jason, Ferris Matthew, Song Yang, Shetty Amol, Mehra Ranee, Papadimitriou John C, Hatten Kyle, Taylor Rodney, Wolf Jeffrey, Sun Kai, Bentzen Soren, Regine William, Tran Phuoc, Witek Matthew

Abstract excerpt

INTRODUCTION: Re-irradiation (re-RT) for recurrent head and neck cancer (rHNC) is challenging. We describe clinical outcomes and toxicity of proton therapy (PT) for recurrent HNC, and report genomic alterations associated with patterns of failure. MATERIALS & METHODS: We performed a retrospective analysis of rHNC patients treated with PT. Outcomes were estimated using the Kaplan-Meier method. Univariate (UVA) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38824813
DOI: 10.1016/j.oraloncology.2024.106875

Genes

ARID1B
NOTCH4
TP53

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