Article
The role of the genomic mutation signature and tumor mutation burden on relapse risk prediction in head and neck squamous cell carcinoma after concurrent chemoradiotherapy.
Experimental & molecular medicine - 1 May 2023
Wang Hui-Ching, Moi Sin-Hua, Chan Leong-Perng, Wu Chun-Chieh, Du Jeng-Shiun, Liu Pei-Lin, Chou Meng-Chun, Wu Che-Wei, Huang Chih-Jen, Hsiao Hui-Hua, Pan Mei-Ren, Chen Li-Tzong
Abstract excerpt
Personalized genetic profiling has focused on improving treatment efficacy and predicting risk stratification by identifying mutated genes and selecting targeted agents according to genetic testing. Therefore, we evaluated the role of genetic profiling and tumor mutation burden (TMB) using next-generation sequencing in patients with head and neck squamous cell carcinoma (HNSC). The relapse mutation signature...
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