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Article

Molecular pathways of senescence regulate placental structure and function

19 Aug 2019

Abstract excerpt

The placenta is an autonomous organ that maintains fetal growth and development. Its multinucleated syncytiotrophoblast layer, providing fetal nourishment during gestation, exhibits characteristics of cellular senescence. We show that in human placentas from pregnancies with intrauterine growth restriction, these characteristics are decreased. To elucidate the functions of pathways regulating senescence in...

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PMID: 31424120
DOI: 10.15252/embj.2018100849

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