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Silencing P38 MAPK reduces cellular senescence in human fetal chorion trophoblast cells

5 Nov 2022

Abstract excerpt

PROBLEM: Amniochorion senescence generates mechanistic signals to initiate parturition. Activation of p38 mitogen-activated kinase (MAPK) in fetal amnion cells is a key mediator of senescence as well as epithelial-mesenchymal transition (EMT) of amnion cells. However, the impact of p38 MAPK in chorion trophoblast cells (CTCs) is unclear. We tested if eliminating p38 will reduce oxidative stress (OS) induced cell...

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PMID: 36334089
DOI: 10.1111/aji.13648

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