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Article

Placental Senescence and the Two‐Stage Model of Preeclampsia

1 Jul 2024

Abstract excerpt

In this review, we summarize how an increasingly stressed and aging placenta contributes to the maternal clinical signs of preeclampsia, a potentially lethal pregnancy complication. The pathophysiology of preeclampsia has been conceptualized in the two-stage model. Originally, highlighting the importance of poor placentation for early-onset preeclampsia, the revised two-stage model explains late-onset...

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PMID: 39049670
DOI: 10.1111/aji.13904

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