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Impact of antiphospholipid syndrome on placenta and uterine NK cell function: insights from a mouse model

28 Dec 2024

Abstract excerpt

Antiphospholipid syndrome (APS) is associated with recurrent pregnancy morbidity, yet the underlying mechanisms remain elusive. We performed multifaceted characterization of the biological and transcriptomic signatures of mouse placenta and uterine natural killer (uNK) cells in APS. Histological analysis of APS placentas unveiled placental abnormalities, including disturbed angiogenesis, occasional necrotic...

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PMID: 39732740
DOI: 10.1038/s41598-024-82451-2

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