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Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor

12 Apr 2023

Abstract excerpt

Most cases of preterm labor have unknown cause, and the burden of preterm birth is immense. Placental aging has been proposed to promote labor onset, but specific mechanisms remain elusive. We report findings stemming from unbiased transcriptomic analysis of mouse placenta, which revealed that hypoxia-inducible factor 1 (HIF-1) stabilization is a hallmark of advanced gestational timepoints, accompanied by...

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PMID: 37610425
DOI: 10.7554/elife.85597

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