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Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human

17 Apr 2024

Abstract excerpt

Peripartum cardiomyopathy (PPCM) is an idiopathic form of pregnancy-induced heart failure associated with preeclampsia. Circulating factors in late pregnancy are thought to contribute to both diseases, suggesting a common underlying pathophysiological process. However, what drives this process remains unclear. Using serum proteomics, we identified the senescence-associated secretory phenotype (SASP), a marker of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38630848
DOI: 10.1126/scitranslmed.adi0077

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