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Does epigenetic dysregulation of pancreatic islets contribute to impaired insulin secretion and type 2 diabetes?

4 Aug 2015

Abstract excerpt

β cell dysfunction is central to the development and progression of type 2 diabetes (T2D). T2D develops when β cells are not able to compensate for the increasing demand for insulin caused by insulin resistance. Epigenetic modifications play an important role in establishing and maintaining β cell identity and function in physiological conditions. On the other hand, epigenetic dysregulation can cause a loss of β...

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PMID: 26369706
DOI: 10.1139/bcb-2015-0057

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