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Glucolipotoxicity-Inhibited miR-299-5p Regulates Pancreatic β-Cell Function and Survival

21 Aug 2018

Abstract excerpt

Inhibition of microRNAs (miRNAs) essential for pancreatic β-cell biology (e.g., miR-375) results in β-cell failure and diabetes in rodent models. Whether the downregulation of miRNAs in pancreatic islets is involved in the development of human type 2 diabetes remains unclear. Here, with the use of an miRNA microarray, we identified a set of miRNAs that were differentially expressed in healthy human islets under...

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PMID: 30131392
DOI: 10.2337/db18-0223

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