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Distribution and dynamics of mitochondrial DNA methylation in oocytes, embryos and granulosa cells

15 Aug 2019

Abstract excerpt

Comparison of mitochondrial DNA (mtDNA) methylation patterns in oocytes, blastocysts and ovarian granulosa cells indicates hitherto unsuspected dynamics. Oocytes and blastocysts recovered from cows subjected to ovarian stimulation and from non-stimulated abattoir ovaries were analyzed using bisulphite transformation of DNA followed by whole genome sequencing. The cow is a recognized as a good model for human...

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PMID: 31417147
DOI: 10.1038/s41598-019-48422-8

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