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DNA methylomes of bovine gametes and in vivo produced preimplantation embryos

14 Jun 2018

Abstract excerpt

DNA methylation is an important epigenetic modification that undergoes dynamic changes in mammalian embryogenesis, during which both parental genomes are reprogrammed. Despite the many immunostaining studies that have assessed global methylation, the gene-specific DNA methylation patterns in bovine preimplantation embryos are unknown. Using reduced representation bisulfite sequencing, we determined genome-scale...

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PMID: 29912291
DOI: 10.1093/biolre/ioy138

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