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Article

DNA methylation establishment during oocyte growth: mechanisms and significance

1 Jan 2012

Abstract excerpt

DNA methylation in the oocyte has a particular significance: it may contribute to gene regulation in the oocyte and marks specific genes for activity in the embryo, as in the case of imprinted genes. Despite the fundamental importance of DNA methylation established in the oocyte, knowledge of the mechanisms by which it is conferred and how much is stably maintained in the embryo has remained very limited. Next...

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PMID: 23417409
DOI: 10.1387/ijdb.120152gk

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