Article
Genetic and clinical predictors of CD4 lymphocyte recovery during suppressive antiretroviral therapy: Whole exome sequencing and antiretroviral therapy response phenotypes.
PloS one - 1 Jan 2019
Greenblatt Ruth, Bacchetti Peter, Boylan Ross, Kober Kord, Springer Gayle, Anastos Kathryn, Busch Michael, Cohen Mardge, Kassaye Seble, Gustafson Deborah, Aouizerat Bradley
Abstract excerpt
Increase of peripheral blood CD4 lymphocyte counts is a key goal of combined antiretroviral therapy (cART); most, but not all, recipients respond adequately and promptly. A small number of studies have examined specific genetic factors associated with the extent of CD4 recovery. We report a genome-wide examination of factors that predict CD4 recovery in HIV-infected women. We identified women in in a cohort study...
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