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Article

Age-dependent atrial arrhythmic phenotype secondary to mitochondrial dysfunction in Pgc-1β deficient murine hearts.

Mechanisms of ageing and development - 1 Oct 2017

Valli Haseeb, Ahmad Shiraz, Chadda Karan R, Al-Hadithi Ali B A K, Grace Andrew A, Jeevaratnam Kamalan, Huang Christopher L-H

Abstract excerpt

INTRODUCTION: Ageing and several age-related chronic conditions including obesity, insulin resistance and hypertension are associated with mitochondrial dysfunction and represent independent risk factors for atrial fibrillation (AF). MATERIALS AND METHODS: Atrial arrhythmogenesis was investigated in Langendorff-perfused young (3-4 month) and aged (>12 month), wild type (WT) and peroxisome proliferator activated...

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Identifiers

PMID: 28919427
DOI: 10.1016/j.mad.2017.09.002
PMCID: PMC5652526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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