Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomeres and Mitochondria in the Aging Heart

26 Apr 2012

Abstract excerpt

Studies in humans and in mice have highlighted the importance of short telomeres and impaired mitochondrial function in driving age-related functional decline in the heart. Although telomere and mitochondrial dysfunction have been viewed mainly in isolation, recent studies in telomerase-deficient mice have provided evidence for an intimate link between these two processes. Telomere dysfunction induces a profound...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Mitochondrial Function and Pathology
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22539756
DOI: 10.1161/circresaha.111.246868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomeres and Mitochondria in the Aging HeartPMID 22539756Read ↗

Aging, telomeres and heart failureSemantic proximity Read ↗

The mitochondrial genome in aging and senescence.Semantic proximity Read ↗

Cardiovascular aging: the mitochondrial influenceSemantic proximity Read ↗

Telomeres and Mitochondrial Metabolism: Implications for Cellular Senescence and Age-related DiseasesSemantic proximity Read ↗

Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathySemantic proximity Read ↗

Cardiac telomere length in heart development, function, and diseaseSemantic proximity Read ↗

Cardiac Aging in Mice and Humans: The Role of Mitochondrial Oxidative StressSemantic proximity Read ↗

Mitochondrial dysfunction in cardiac agingSemantic proximity Read ↗

Heart-Breaking TelomeresSemantic proximity Read ↗

Mitochondrial Drivers of Aging: An Integrative Bioenergetic and Genomic Framework for Healthspan RegulationSemantic proximity Read ↗

Telomerase as a Therapeutic Target in Cardiovascular Disease.Semantic proximity Read ↗

The interplay between autophagy and mitochondrial dysfunction in oxidative stress-induced cardiac aging and pathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.