Article

Copy number aberrations drive kinase re-wiring leading to genetic vulnerabilities in cancer

2019-01-09

Abstract excerpt

Somatic DNA copy number variations (CNVs) are prevalent in cancer and can drive cancer progression albeit with often uncharacterized roles in altering cell signaling states. Here, we integrated genomic and proteomic data for 5598 tumor samples to identify CNVs leading to aberrant signal transduction. The resulting associations recapitulated known kinase-substrate relationships and further network analysis prioriti...

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Literature Corpus work: 7006282d-aea3-5365-9950-ea75fd43e87d
DOI: 10.1101/515932

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