Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low duplicability and network fragility of cancer genes.

Trends in genetics : TIG - 1 Sept 2008

Rambaldi Davide, Giorgi Federico M, Capuani Fabrizio, Ciliberto Andrea, Ciccarelli Francesca D

Abstract excerpt

We identified genomic and network properties of approximately 600 genes mutated in different cancer types. These genes tend not to duplicate but, unlike most human singletons, they encode central hubs of highly interconnected modules within the protein-protein interaction network (PIN). We find that cancer genes are fragile components of the human gene repertoire, sensitive to dosage modification. Furthermore,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Regulatory Networks
Share to Genes, Duplicate
Share to Genes, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to Protein Binding

Source

Identifiers

PMID: 18675489
DOI: 10.1016/j.tig.2008.06.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low duplicability and network fragility of cancer genes.PMID 18675489Read ↗

Network of Cancer Genes: a web resource to analyze duplicability, orthology and network properties of cancer genes.Semantic proximity Read ↗

Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancerSemantic proximity Read ↗

The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screensSemantic proximity Read ↗

Studying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactome.Semantic proximity Read ↗

NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes.Semantic proximity Read ↗

Identification of hyper-rewired genomic stress non-oncogene addiction genes across 15 cancer typesSemantic proximity Read ↗

Cancer relevance of human genesSemantic proximity Read ↗

Network of Cancer Genes (NCG 3.0): integration and analysis of genetic and network properties of cancer genes.Semantic proximity Read ↗

Characterising and predicting haploinsufficiency in the human genome.Semantic proximity Read ↗

The human disease network.Semantic proximity Read ↗

Cancer Relevance of Human Genes.Semantic proximity Read ↗

The aging genome exhibits organized vulnerability to somatic mutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.