Article

Proteome-anchored multi-omics of recurrent somatic alterations defines tumour states in cervical cancer and enables state-guided drug repurposing

2026-04-23

Abstract excerpt

Cervical cancer exhibits substantial molecular heterogeneity, and somatic mutation frequency alone is an incomplete surrogate for functional consequence or therapeutic vulnerability. Here, we present a proteome-anchored bioinformatics framework that integrates genomic, epigenomic, transcriptomic, and proteomic data to infer functionally expressed tumour states and to nominate candidate state-reversing perturbagens...

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Literature Corpus work: 9a64f516-971c-5f84-b866-336dcd05e21c
DOI: 10.64898/2026.04.21.719801

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