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Article

Autoantigens PLA2R and THSD7A in membranous nephropathy share a common epitope motif in the N-terminal domain

5 Aug 2019

Abstract excerpt

Patients with membranous nephropathy have autoantibodies against PLA2R (up to 80%), or THSD7A (up to 2%). We previously described the immunodominant epitope within PLA2R but epitopes in THSD7A are still unknown. To find anti-THSD7A sera for this study, we screened 1843 sera from biopsy-proven MN patients by ELISA and identified 22 sera as anti-THSD7A positive representing 1.2% of MN cases. Anti-THSD7A positive...

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Identifiers

PMID: 31395435
DOI: 10.1016/j.jaut.2019.102308

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