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Article

PLA2R and THSD7A: Disparate Paths to the Same Disease?

3 Jul 2017

Abstract excerpt

The phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) are the two major autoantigens in primary membranous nephropathy (MN), and define two molecular subclasses of this disease. Both proteins are large transmembrane glycoproteins expressed by the podocyte, and both induce IgG4-predominant humoral immune responses that produce circulating autoantibodies that can be used...

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Identifiers

PMID: 28674044
DOI: 10.1681/asn.2017020178

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