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Article

Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts.

Aging cell - 1 Dec 2019

Narisu Narisu, Rothwell Rebecca, Vrtačnik Peter, Rodríguez Sofía, Didion John, Zöllner Sebastian, Erdos Michael R, Collins Francis S, Eriksson Maria

Abstract excerpt

Somatic mutations are critical for cancer development and may play a role in age-related functional decline. Here, we used deep sequencing to analyze the prevalence of somatic mutations during in vitro cell aging. Primary dermal fibroblasts from healthy subjects of young and advanced age, from Hutchinson-Gilford progeria syndrome and from xeroderma pigmentosum complementation groups A and C, were first restricted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31385397
DOI: 10.1111/acel.13010
PMCID: PMC6826141

Genes

CDKN2A
BRCA2
ERCC8
XPA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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