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Article

Somatic Variants in the Human Lens Epithelium: A Preliminary Assessment.

Investigative ophthalmology & visual science - 1 Aug 2016

Mesa Rosana, Tyagi Manoj, Harocopos George, Vollman David, Bassnett Steven

Abstract excerpt

PURPOSE: We hypothesize that somatic mutations accumulate in cells of the human lens and may contribute to the development of cortical or posterior sub-capsular cataracts. Here, we used a Next-generation sequencing (NGS) strategy to screen for low-allelic frequency variants in DNA extracted from human lens epithelial samples. METHODS: Next-Generation sequencing of 151 cancer-related genes (WUCaMP2 panel) was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27537255
DOI: 10.1167/iovs.16-19726
PMCID: PMC4986767

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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