Article

Ultra-deep duplex sequencing reveals unique features of somatic evolution in the normal tissues of a family with Li-Fraumeni syndrome

2026-01-13

Abstract excerpt

<h4>ABSTRACT</h4> Li-Fraumeni Syndrome (LFS) is caused by germline pathogenic variants in TP53 which predispose carriers to early onset cancer across multiple tissues. While genomically profiling those cancers has revealed factors contributing to their formation, little is understood about how LFS impacts clonal evolution in healthy tissues preceding cancer. Here, we use ultra-deep duplex sequencing (mean ∼15,00...

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Literature Corpus work: 20fae3c3-0e37-58e9-a30d-956fc6a411ba
DOI: 10.64898/2026.01.12.699071

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