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Article

Functional Heterogeneity of PAX5 Chimeras Reveals Insight for Leukemia Development

16 Jan 2014

Abstract excerpt

UNLABELLED: PAX5, a transcription factor pivotal for B-cell commitment and maintenance, is one of the most frequent targets of somatic mutations in B-cell precursor acute lymphoblastic leukemia. A number of PAX5 rearrangements result in the expression of in-frame fusion genes encoding chimeric proteins, which at the N-terminus consistently retain the PAX5 DNA-binding paired domain fused to the C-terminal domains...

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PMID: 24435167
DOI: 10.1158/1541-7786.mcr-13-0337

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