Article
Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: a prospective cohort study.
BMJ open - 31 Jul 2019
Huang Tao, Wang Tiange, Heianza Yoriko, Wiggs Janey, Sun Dianjianyi, Choi Hyon-Kyoo, Chai Jin Fang, Sim Xueling, Khor Chiea Chuen, Friedlander Yechiel, Chan Andrew T, Curhan Gary, Vivo Immaculata De, van Dam Rob Martinu, Heng Chew Kiat, Fuchs Charles, Pasquale Louis R, Yuan Jian-Min, Hu Frank B, Koh Woon Puay, Qi Lu
Abstract excerpt
OBJECTIVE: We tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI). DESIGN: Three FADS variants were examined for gene-diet interactions on long-term (~10 years) changes in BMI and body...
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