Article
Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study.
The American journal of clinical nutrition - 1 Jul 2010
Lu Yingchang, Feskens Edith Jm, Dollé Martijn Et, Imholz Sandra, Verschuren Wm Monique, Müller Michael, Boer Jolanda Ma
Abstract excerpt
BACKGROUND: The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or eryth...
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