Article
Predicting fatty acid profiles in blood based on food intake and the FADS1 rs174546 SNP.
Molecular nutrition & food research - 1 Dec 2015
Hallmann Jacqueline, Kolossa Silvia, Gedrich Kurt, Celis-Morales Carlos, Forster Hannah, O'Donovan Clare B, Woolhead Clara, Macready Anna L, Fallaize Rosalind, Marsaux Cyril F M, Lambrinou Christina-Paulina, Mavrogianni Christina, Moschonis George, Navas-Carretero Santiago, San-Cristobal Rodrigo, Godlewska Magdalena, Surwiłło Agnieszka, Mathers John C, Gibney Eileen R, Brennan Lorraine, Walsh Marianne C, Lovegrove Julie A, Saris Wim H M, Manios Yannis, Martinez Jose Alfredo, Traczyk Iwona, Gibney Michael J, Daniel Hannelore
Abstract excerpt
SCOPE: A high intake of n-3 PUFA provides health benefits via changes in the n-6/n-3 ratio in blood. In addition to such dietary PUFAs, variants in the fatty acid desaturase 1 (FADS1) gene are also associated with altered PUFA profiles. METHODS AND RESULTS: We used mathematical modeling to predict levels of PUFA in whole blood, based on multiple hypothesis testing and bootstrapped LASSO selected food items,...
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