Article

OMVs-Delivered Vibrio splendidus sRNA063 OrchestratesPDZRN3-Mediated K48-Linked Polyubiquitination of ATG2 toSuppress Autophagy in Echinoderms

2026-02-23

Abstract excerpt

<title>Abstract</title> <p>Pathogenic small RNAs (sRNAs) are emerging as cross-kingdom regulators of host immunity, yet the underlying mechanism remains incompletely defined. Here, we identify sRNA063 as a key virulence gene of Vibrio splendidus during the infection of its host, sea cucumber Apostichopus japonicus. sRNA063 is delivered to host coelomocytes via outer membrane vesicles (OMVs) and directly binds the...

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Literature Corpus work: 02fc736e-25a7-579b-a577-4adff90fa5af
DOI: 10.21203/rs.3.rs-8922027/v1

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