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Article

The Relationship Between Mismatch Repair Deficiency and PD-L1 Expression in Breast Carcinoma.

The American journal of surgical pathology - 1 Feb 2018

Mills Anne M, Dill Erik A, Moskaluk Christopher A, Dziegielewski Jaroslaw, Bullock Tim N, Dillon Patrick M

Abstract excerpt

Mismatch repair (MMR) deficiency in solid tumors has recently been linked to susceptibility to immunotherapies targeting the programmed cell death-1 (PD-1)/programmed cell death-1 ligand (PD-L1) axis. Loss of MMR proteins has been shown to correlate with tumoral PD-L1 expression in colorectal and endometrial carcinomas, but the association between expression of MMR proteins and PD-L1 has not previously been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28914717
DOI: 10.1097/PAS.0000000000000949

Genes

MLH1
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Microsatellite instability status predicts response to anti-PD-1/PD-L1 therapy regardless the histotype: A comment on recent advancesSemantic proximity Read ↗

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