Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HER2/HER3 regulates lactate secretion and expression of lactate receptor mRNA through the MAP3K4 associated protein GIT1

25 Jul 2019

Abstract excerpt

One of the major features of cancer is Otto Warburg's observation that many tumors have increased extracellular acidification compared to healthy tissues. Since Warburg's observation, the importance of extracellular acidification in cancer is now considered a hallmark of cancer. Human MAP3K4 functions upstream of the p38 and JNK mitogen activated protein kinases (MAPKs). Additionally, MAP3K4 is required for cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to interferon and immune responses
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31346208
DOI: 10.1038/s41598-019-46954-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HER2/HER3 regulates lactate secretion and expression of lactate receptor mRNA through the MAP3K4 associated protein GIT1PMID 31346208Read ↗

YAP1-TEAD1-Glut1 axis dictates the oncogenic phenotypes of breast cancer cells by modulating glycolysis.Semantic proximity Read ↗

Lactate metabolism subtypes analysis reveals CCDC80 as a novel prognostic biomarker in gastric cancerSemantic proximity Read ↗

Proton sensing GPCR’s: The missing link to Warburg’s oncogenic legacy?Semantic proximity Read ↗

Lactate Metabolism Regulates Tumour Growth and Progression in GlioblastomaSemantic proximity Read ↗

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1αSemantic proximity Read ↗

Intracellular lactate-mediated induction of estrogen receptor beta (ERβ) in biphasic malignant pleural mesothelioma cells.Semantic proximity Read ↗

Lactate-Driven Heterogeneity of Immune Checkpoint Expression in Breast and Lung Cancer Cell LinesSemantic proximity Read ↗

H19 contributes to aerobic glycolysis, proliferation and immune escape of gastric cancer cells via the miR-519d-3p/LDHA axisSemantic proximity Read ↗

GPR81-mediated reprogramming of glucose metabolism contributes to the immune landscape in breast cancerSemantic proximity Read ↗

Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer CellsSemantic proximity Read ↗

Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survivalSemantic proximity Read ↗

Intracellular pH differentially regulates transcription of metabolic and signaling pathways in normal epithelial cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.