Article
Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers.
International journal of molecular sciences - 30 May 2020
Park Hong-Beom, Kim Ju-Won, Baek Kwang-Hyun
Abstract excerpt
The Wnt signaling pathway plays important roles in embryonic development, homeostatic processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β-catenin binding of Wnt target genes. Dysregulation of Wnt signaling is associated with various diseases such as cancer, aging, Alzheimer's disease, metabolic disease, and pigmentation disorders. Numerous studies entailing the Wnt...
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