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Article

Resident macrophages reprogram toward a developmental state after acute kidney injury

23 Jan 2019

Abstract excerpt

Acute kidney injury (AKI) is a devastating clinical condition affecting at least two-thirds of critically ill patients, and, among these patients, it is associated with a greater than 60% risk of mortality. Kidney mononuclear phagocytes (MPs) are implicated in pathogenesis and healing in mouse models of AKI and, thus, have been the subject of investigation as potential targets for clinical intervention. We have...

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PMID: 30674729
DOI: 10.1172/jci.insight.125503

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