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Article

RUNX2 contributes to TGF-β1-induced expression of Wdr72 in ameloblasts during enamel mineralization

20 Jul 2019

Abstract excerpt

The elaborate modulation of the transforming growth factor β (TGF-β) superfamily signaling network plays an essential role in tooth morphogenesis and differentiation. In our previous studies, we have demonstrated that TGF-β1 promotes enamel mineralization and maturation using TGF-β1 gene conditional knockout (TGF-β1-cKO) mice. However, the specific regulatory mechanisms of TGF-β1 during enamel development remain...

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PMID: 31336344
DOI: 10.1016/j.biopha.2019.109235

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