Article
Phenotypic changes in dentition of Runx2 homozygote-null mutant mice.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Jan 2004
Aberg Thomas, Cavender Adriana, Gaikwad Joel S, Bronckers Antonius L J J, Wang Xiuping, Waltimo-Sirén Janna, Thesleff Irma, D'Souza Rena N
Abstract excerpt
Genetic and molecular studies in humans and mice indicate that Runx2 (Cbfa1) is a critical transcriptional regulator of bone and tooth formation. Heterozygous mutations in Runx2 cause cleidocranial dysplasia (CCD), an inherited disorder in humans and mice characterized by skeletal defects, supernumerary teeth, and delayed eruption. Mice lacking the Runx2 gene die at birth and lack bone and tooth development. Our...
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