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Article

Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption.

Matrix biology : journal of the International Society for Matrix Biology - 1 Jan 2000

Xu H, Snider T N, Wimer H F, Yamada S S, Yang T, Holmbeck K, Foster B L

Abstract excerpt

Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a transmembrane zinc-endopeptidase that breaks down extracellular matrix components, including several collagens, during tissue development and physiological remodeling. MT1-MMP-deficient mice (MT1-MMP(-/-)) feature severe defects in connective tissues, such as impaired growth, osteopenia, fibrosis, and conspicuous loss of molar tooth eruption and root...

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Identifiers

PMID: 26780723
DOI: 10.1016/j.matbio.2016.01.002
PMCID: PMC4875876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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