Article
Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1/5/8 phosphorylation.
Scientific reports - 31 Mar 2016
Liu Jia, Saito Kan, Maruya Yuriko, Nakamura Takashi, Yamada Aya, Fukumoto Emiko, Ishikawa Momoko, Iwamoto Tsutomu, Miyazaki Kanako, Yoshizaki Keigo, Ge Lihong, Fukumoto Satoshi
Abstract excerpt
Bone morphogenetic proteins (BMPs) regulate hard tissue formation, including bone and tooth. Growth differentiation factor 5 (GDF5), a known BMP, is expressed in cartilage and regulates chondrogenesis, and mutations have been shown to cause osteoarthritis. Notably, GDF5 is also expressed in periodontal ligament tissue; however, its role during tooth development is unclear. Here, we used cell culture and in vivo...
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