Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin.

doi:10.1073/pnas.0800135105

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin.

Proceedings of the National Academy of Sciences of the United States of America - 11 Mar 2008

Garzon Ramiro, Garofalo Michela, Martelli Maria Paola, Briesewitz Roger, Wang Lisheng, Fernandez-Cymering Cecilia, Volinia Stefano, Liu Chang-Gong, Schnittger Susanne, Haferlach Torsten, Liso Arcangelo, Diverio Daniela, Mancini Marco, Meloni Giovanna, Foa Robin, Martelli Massimo F, Mecucci Cristina, Croce Carlo M, Falini Brunangelo

Abstract excerpt

Acute myeloid leukemia (AML) carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ AML) accounts for about one-third of adult AML and shows distinct features, including a unique gene expression profile. MicroRNAs (miRNAs) are small noncoding RNAs of 19-25 nucleotides in length that have been linked to the development of cancer. Here, we investigated the role of miRNAs in the biology of NPMc+ AML. The miRNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoplasm

Share to fms-Like Tyrosine Kinase 3

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Mutant Proteins

Share to Myeloid Ecotropic Viral Integration Site 1 Protein

Share to Nucleophosmin

Source

Open in PubMed Open full text

Identifiers

PMID: 18308931
DOI: 10.1073/pnas.0800135105
PMCID: PMC2268779

Genes

FLT3
NPM1
HOXA10
MEIS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin.PMID 18308931Read ↗

Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia.Semantic proximity Read ↗

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemiaSemantic proximity Read ↗

Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features.Semantic proximity Read ↗

NPM1-mutated acute myeloid leukemia: New pathogenetic and therapeutic insights and open questions.Semantic proximity Read ↗

miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death.Semantic proximity Read ↗

Acute myeloid leukemia with mutated NPM1: diagnosis, prognosis and therapeutic perspectives.Semantic proximity Read ↗

Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity.Semantic proximity Read ↗

Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survivalSemantic proximity Read ↗

Role of nucleophosmin in acute myeloid leukemia.Semantic proximity Read ↗

NPM1-mutated acute myeloid leukemia: from bench to bedside.Semantic proximity Read ↗

Prognostic significance of NPM1 mutation-modulated microRNA-mRNA regulation in acute myeloid leukemia.Semantic proximity Read ↗

Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.