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Involvement of G-quadruplex regions in mammalian replication origin activity

22 Jul 2019

Abstract excerpt

Genome-wide studies of DNA replication origins revealed that origins preferentially associate with an Origin G-rich Repeated Element (OGRE), potentially forming G-quadruplexes (G4). Here, we functionally address their requirements for DNA replication initiation in a series of independent approaches. Deletion of the OGRE/G4 sequence strongly decreased the corresponding origin activity. Conversely, the insertion of...

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PMID: 31332171
DOI: 10.1038/s41467-019-11104-0

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