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Article

G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV

2 Feb 2016

Abstract excerpt

Kaposi's sarcoma associated herpesvirus (KSHV) establishes life-long latent infection by persisting as an extra-chromosomal episome in the infected cells and by maintaining its genome in dividing cells. KSHV achieves this by tethering its epigenome to the host chromosome by latency associated nuclear antigen (LANA), which binds in the terminal repeat (TR) region of the viral genome. Sequence analysis of the TR, a...

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PMID: 26837574
DOI: 10.1093/nar/gkw038

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