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G-quadruplex as an essential structural element in cytomegalovirus replication origin

27 Aug 2024

Abstract excerpt

G-quadruplex (G4) structures are found in eukaryotic cell replication origins, but their role in origin function remains unclear. In this study G4 motifs are found in the lytic DNA replication origin (oriLyt) of human cytomegalovirus (HCMV) and recombinant viruses show that a G4 motif in oriLyt essential region I (ER-I) is necessary for viral growth. Replication assays of oriLyt-containing plasmids and...

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PMID: 39191758
DOI: 10.1038/s41467-024-51797-6

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