Investigating the Feasibility of Targeted Next-Generation Sequencing to Guide the Treatment of Head and Neck Squamous Cell Carcinoma.

doi:10.4143/crt.2018.012

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Investigating the Feasibility of Targeted Next-Generation Sequencing to Guide the Treatment of Head and Neck Squamous Cell Carcinoma.

Cancer research and treatment - 1 Jan 2019

Lim Sun Min, Cho Sang Hee, Hwang In Gyu, Choi Jae Woo, Chang Hyun, Ahn Myung-Ju, Park Keon Uk, Kim Ji-Won, Ko Yoon Ho, Ahn Hee Kyung, Cho Byoung Chul, Nam Byung-Ho, Chun Sang Hoon, Hong Ji Hyung, Kwon Jung Hye, Choi Jong Gwon, Kang Eun Joo, Yun Tak, Lee Keun-Wook, Kim Joo-Hang, Kim Jin Soo, Lee Hyun Woo, Kim Min Kyoung, Jung Dongmin, Kim Ji Eun, Keam Bhumsuk, Yun Hwan Jung, Kim Sangwoo, Kim Hye Ryun

Abstract excerpt

PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is a deadly disease in which precision medicine needs to be incorporated. We aimed to implement next-generation sequencing (NGS) in determining actionable targets to guide appropriate molecular targeted therapy in HNSCC patients. MATERIALS AND METHODS: Ninety-three tumors and matched blood samples underwent targeted sequencing of 244 genes using the Illumina...

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PMID: 29747488
DOI: 10.4143/crt.2018.012
PMCID: PMC6333965

Genes

CCND1
FAT1
NOTCH1

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